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Orbach Lab

“The greatest obstacle to discovery is not ignorance -
it is the illusion of knowledge ”

Daniel J. Boorstin

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Research

Our lab is fascinated by self-assembly and dynamic behavior of the microtubule cytoskeleton. We are especially interested in the ciliary cytoskeleton, known as the axoneme. Using cutting-edge microscopy techniques, advanced biochemistry, quantitative image analysis and various multidisciplinary approaches we aim to answer basic questions related to the cilia.

Highlighted Publication

The Dynamic and Structural Properties of Axonemal Tubulins Support the High Length Stability of Cilia

The work describes a novel biochemical assay to purify axonemal tubulins from the central pair and the doublets.  Using in vitro work, we characterize two distinct mechanisms that enable tubulins to support the length stability of the axoneme. 

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