New Review: Microtubule Inner Proteins – Bridging Structure and Function in Ciliary Biology

We are thrilled to share the first publication from the Orbach Lab, a Journal of Cell Science Review titled “Microtubule Inner Proteins – Bridging Structure and Function in Ciliary Biology,” written together with Miao Gui.

This Review highlights the remarkable progress in understanding how microtubule inner proteins (MIPs) organize the ciliary doublet microtubules from within—stabilizing the axoneme, shaping its periodic architecture, and fine-tuning ciliary motility. We summarize recent cryo-EM breakthroughs that uncovered the intricate network of conserved and lineage-specific MIPs, their roles in ciliary assembly and function, and the diseases that arise when they are disrupted.

We are deeply grateful to the guest editors, Pleasantine Mill and Lotte B. Pedersen, for curating this inspiring Special Issue on cilia and flagella.

🔗 Read the full article in Journal of Cell Science

Gui & Orbach, 2025, J. Cell Sci. 138: jcs264192